5-7 MILLION PEOPLE ARE AFFECTED BY ESSENTIAL TREMOR IN THE U.S. ALONE.
What is essential tremor? Essential tremor (ET) is a neurological condition that most commonly causes a rhythmic trembling of the hands while performing a task such as eating, writing, dressing, drinking or when holding a posture such as with the arms outstretched in front of the body. The tremor can also affect the head, voice, legs and trunk. Some people even feel an internal shake. ET is often confused with Parkinson’s disease although it’s eight times more common, affecting an estimated 5-7 million Americans and millions more worldwide. It was once known as familial tremor, benign tremor or hereditary tremor. Essential tremor is more than just a tremor. It is a life-changing condition. Because of stereotypes and a lack of awareness, many people with ET never seek medical care.
DISCOVERIES IN SK CHANNELS
In people with essential tremor (ET), the neurons of the cerebellum have altered rhythmicity and regularity, resulting in the loss of motor control, impacting mobility and fine motor function.
Cadent Therapeutics has discovered compounds that modulate SK (small-conductance calcium-activated potassium) channels that play a central role in maintaining regular neuronal firing. SK channels are expressed throughout the central nervous system and are responsible for regulating the amount of potassium that enters a cell and affect the inherent excitability of neurons and communication between synapses. Through SK channel modulation, we hope to control the firing rate (amount of times a neuron fires at any given time) and the firing pattern (allocation of firing over time), thereby restoring balance to the brain’s rhythms.